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 Determination of bacterial rod shape by a novel cytoskeletal membrane protein
Here, Hironori and coworkers identify RodZ as a novel cell shape-determining protein in E. coli. Surprisingly in light of its primary sequence and membrane protein topology, RodZ forms cytoskeletal spirals similar to the bacterial actin homolog MreB, and exhibits a similar loss-of-function phenotype with loss of bacterial rod shape. |
| Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction
The mechanisms linking mechanical stress to ion channel activation are not well understood. Gudermann and colleagues now report that GPCRs, and not TRP ion channels, are the primary mechanosensors in vascular smooth muscle, mediating activation of TRPC channels via intracellular signalling. |
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Cancer induction by restriction of oncogene expression to the stem cell compartment
Here, Sanchez-Garcia and colleagues show that restricting oncogenic BCR-ABL expression to stem cells is sufficient to induce highly penetrant leukemia. This disease can be treated by ablation of the stem cell compartment, providing further support for the cancer stem cell hypothesis. |
| Common thiolation mechanism in the biosynthesis of tRNA thiouridine and sulphur-containing cofactors
The ubiquitin-related urmylation pathway has recently been implicated in tRNA sulphur modification in yeast. Shigi et al. describe here a similar mechanism for bacterial tRNAs, which interestingly also seems to contribute activated sulphur to the evolutionary related thiamin cofactor biosynthesis. |
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| This collection of eight review articles - Focus on Quality Control - highlights different aspects of cellular quality control and their potential relevance for human diseases. Topics include mitochondrial and ER quality control, protein folding and degradation; as well as quality control in RNA and DNA metabolism. These online review articles include downloadable figures for teaching purposes and links to relevant research articles published recently in The EMBO Journal and other Nature Publishing Group titles. |
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