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Welcome to The EMBO Journal

We are pleased to announce our brand new FOCUS on Quality Control. This collection of eight review articles highlights different aspects of cellular quality control and their relevance for human diseases. It includes reviews on mitochondrial and ER quality control, protein folding and degradation, as well as quality control in RNA and DNA metabolism.
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Volume 27, Number 12
(18 June 2008)
ISSN 0261 - 4189
Online ISSN 1460 - 2075
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In this issue
beta-Catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions
Here, Arai and colleagues link the poorly understood phospholipase A1 to asymmetric beta-Catenin localization and retrograde transport. Intriguingly, the retromer complex, recently implicated in Wnt secretion in signaling cells, thus functions also in cells that use downstream Wnt pathway components to polarize their division.
Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells
Masanobu Oshima and coworkers report an important role for activated, infiltrating macrophages in gastrointestinal tumorigenesis. By releasing TNF-alpha, they promote Wnt/beta-catenin signaling in gastric cancer cells via enhanced GSK3beta phosphorylation and beta-catenin stabilization.
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Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
The MRN complex promotes ATM activity by unknown mechanisms. Vincenzo Costanzo and colleagues now report that 'byproducts' of MRN's known task, the processing of DNA double strand breaks, function in inducing and sustaining ATM activation.
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Focus on quality control
This collection of eight review articles - Focus on Quality Control - highlights different aspects of cellular quality control and their potential relevance for human diseases. Topics include mitochondrial and ER quality control, protein folding and degradation; as well as quality control in RNA and DNA metabolism. The reviews will be printed in three subsequent regular issues of The EMBO Journal starting with the second issue in January 2008 (27.2). These online review articles include downloadable figures for teaching purposes and links to relevant research articles published recently in The EMBO Journal and other Nature Publishing Group titles.
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The EMBO Journal, EMBO reports provides sharply focused short papers and review articles in all areas of molecular biology. Its quality is reflected in its impact factor of 8.175*

*Journal Citation Reports, Thomson 2007

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