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 Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase
Roco is a bacterial homologue of the human LRRK2 kinase, mutated in Parkinson's Disease. Here, Wittinghofer and colleagues show that Roco dimerizes via its COR domain, and provide new insight into how disease-associated mutations may affect LRRK2. |
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Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways
How ribonucleotide shortage, which impedes transcription in general, nevertheless increases transcription of key NTP biosyntheses genes, is an intensely investigated open question. Intriguingly, a yeast screen by Kwapisz et al. now suggests that not only the promoters of such genes, but also RNA polymerase II itself may act as sensors of NTP depletion. |
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| This collection of eight review articles - Focus on Quality Control - highlights different aspects of cellular quality control and their potential relevance for human diseases. Topics include mitochondrial and ER quality control, protein folding and degradation; as well as quality control in RNA and DNA metabolism. The reviews will be printed in three subsequent regular issues of The EMBO Journal starting with the second issue in January 2008 (27.2). These online review articles include downloadable figures for teaching purposes and links to relevant research articles published recently in The EMBO Journal and other Nature Publishing Group titles. |
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